|
|
|
R3A |
Arg3Ala |
CAA33507.1 |
A. nidulans |
With E4A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
R3A |
Arg3Ala |
CAA19365.1 |
S. pombe |
With E4A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
S1 |
E4A |
Glu4Ala |
CAA33507.1 |
A. nidulans |
With R3A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
S1 |
E4A |
Glu4Ala |
CAA19365.1 |
S. pombe |
With R3A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
S1 |
Q9L |
Gln9Leu |
NP_598789.1 (Tubg2) |
M. musculus |
IGL02302:Tubg2, viable heterozygote, ENU mutatgenesis |
Mutagenetix |
Mus musculus, mouse |
|
|
|
H1 |
Q12G |
Gln12Gly |
AAB67442.1 (Tub4p) |
S. cerevisiae |
With C13G and T146A, GTP binding |
Gombos et al. 2013. Nat Cell Biol 15:1317-27 |
Saccharomyces cerevisiae, yeast, fungus |
|
|
|
H1 |
C13A |
Cys13Ala |
AAB65830.1 |
T. thermophila |
Weak cold sensitive, loss of basal bodies |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H1 |
C13G |
Cys13Gly |
AAB67442.1 (Tub4p) |
S. cerevisiae |
With Q12G and T146A, GTP binding |
Gombos et al. 2013. Nat Cell Biol 15:1317-27 |
Saccharomyces cerevisiae, yeast, fungus |
|
|
|
H1 |
C13S |
Cys13Ser |
AAB67442.1 (Tub4p) |
S. cerevisiae |
With D70N, GTP binding; with T146A, GTP binding |
Gombos et al. 2013. Nat Cell Biol 15:1317-27 |
Saccharomyces cerevisiae, yeast, fungus |
|
|
|
H1 |
N15K |
Asn15Lys |
NP_598785.1 (Tubg1) |
M. musculus |
R5271:Tubg1, viable heterozygote, ENU mutatgenesis |
Mutagenetix |
Mus musculus, mouse |
|
|
|
H1 |
E20A |
Glu20Ala |
CAA19365.1 |
S. pombe |
With E20A, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H1 |
K23A |
Lys23Ala |
CAA19365.1 |
S. pombe |
With K23A, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H1 |
Q24V |
Gln24Val |
AAB65830.1 |
T. thermophila |
Wild type |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H1 |
E28A |
Glu28Ala |
CAA33507.1 |
A. nidulans |
Wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H1 |
H29A |
His29Ala |
CAA33507.1 |
A. nidulans |
Wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
E38A |
Glu38Ala |
CAA33507.1 |
A. nidulans |
With E39A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
E38A |
Glu38Ala |
CAA19365.1 |
S. pombe |
With E39A and E43A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
E39A |
Glu39Ala |
CAA33507.1 |
A. nidulans |
With E38A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
E39A |
Glu39Ala |
CAA19365.1 |
S. pombe |
With E38A and E39A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
E43A |
Glu43Ala |
CAA33507.1 |
A. nidulans |
With D46A and R47A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
E43A |
Glu43Ala |
CAA19365.1 |
S. pombe |
With E38A and E39A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
D46A |
Asp46Ala |
CAA33507.1 |
A. nidulans |
With E43A and R47A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
D46A |
Asp46Ala |
CAA19365.1 |
S. pombe |
With R47A, K48A, D49A, recessive cold sensitive |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
R47A |
Arg47Ala |
CAA33507.1 |
A. nidulans |
With E43A and D46A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
R47A |
Arg47Ala |
CAA19365.1 |
S. pombe |
With D46A, K48A, D49A, recessive cold sensitive |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
K48A |
Lys48Ala |
CAA33507.1 |
A. nidulans |
With D49A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
K48A |
Lys48Ala |
CAA19365.1 |
S. pombe |
With D46A, R47A, D49A, recessive cold sensitive |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
K48A |
Lys48Ala |
AAB65830.1 |
T. thermophila |
With E49A, lethal |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
|
D49A |
Asp49Ala |
CAA33507.1 |
A. nidulans |
With K48A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
D49A |
Asp49Ala |
CAA19365.1 |
S. pombe |
With D46A, R47A, K48A, recessive cold sensitive |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
E49A |
Glu49Ala |
AAB65830.1 |
T. thermophila |
With K48A, lethal |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
S4 |
D56A |
Asp56Ala |
CAA33507.1 |
A. nidulans |
With D57A and R59A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
S4 |
D56A |
Asp56Ala |
CAA19365.1 |
S. pombe |
With D57A and E58A, dominant cold sensitive as diploid |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
S4 |
D56A |
Asp56Ala |
AAB65830.1 |
T. thermophila |
With D57A, wild type |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
|
D57A |
Asp57Ala |
CAA33507.1 |
A. nidulans |
With D56A and R59A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
D57A |
Asp57Ala |
CAA19365.1 |
S. pombe |
With D56A and E58A, dominant cold sensitive as diploid |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
D57A |
Asp57Ala |
AAB65830.1 |
T. thermophila |
With D56A, wild type |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
S5 |
E58A |
Glu58Ala |
CAA19365.1 |
S. pombe |
With D56A and D57A, dominant cold sensitive as diploid |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
S5 |
H59A |
His59Ala |
AAB65830.1 |
T. thermophila |
With R63A, lethal |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
S5 |
R59A |
Arg59Ala |
CAA33507.1 |
A. nidulans |
With D56A and D57A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
S5 |
R63A |
Arg63Ala |
CAA33507.1 |
A. nidulans |
Cold sensitive and heat sensitive |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
S5 |
R63A |
Arg63Ala |
AAB65830.1 |
T. thermophila |
With H59A, lethal |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
S6 |
D68A |
Asp68Ala |
CAA33507.1 |
A. nidulans |
With E70A and R72A, recessive lethal |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
S6 |
D68A |
Asp68Ala |
CAA19365.1 |
S. pombe |
With E70A, P71A, R72A, recessive cold sensitive |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
D70N |
Asp70Asn |
AAB67442.1 (Tub4p) |
S. cerevisiae |
With C13S, GTP binding |
Gombos et al. 2013. Nat Cell Biol 15:1317-27 |
Saccharomyces cerevisiae, yeast, fungus |
|
|
|
|
E70A |
Glu70Ala |
CAA33507.1 |
A. nidulans |
With D68A and R72A, recessive lethal |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
E70A |
Glu70Ala |
CAA19365.1 |
S. pombe |
With D68A, P71A, R72A, recessive cold sensitive |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H2 |
P71A |
Pro71Ala |
CAA19365.1 |
S. pombe |
With D68A, E70A, R72A, recessive cold sensitive |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H2 |
G72G* |
Gly72 |
ABN11809.1 (G2) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
H2 |
R72A |
Arg72Ala |
CAA33507.1 |
A. nidulans |
With D68A and E70A, recessive lethal |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H2 |
R72A |
Arg72Ala |
CAA19365.1 |
S. pombe |
With D68A, E70A, P71A, recessive cold sensitive |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H2 |
R72A |
Arg72Ala |
AAB65830.1 |
T. thermophila |
Lethal |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H2 |
I74T |
Ile74Thr |
NP_598785.1 (Tubg1) |
M. musculus |
R6564:Tubg1, viable heterozygote, ENU mutatgenesis |
Mutagenetix |
Mus musculus, mouse |
|
|
|
H2 |
K76K* |
Lys76 |
ABN11809.1 (G2) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
H2 |
V76V* |
Val76 |
ABN11808.1 (G1) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
|
A81A* |
Ala81 |
ABN11808.1 (G1) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
|
A81A* |
Ala81 |
ABN11809.1 (G2) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
|
G84G* |
Gly84 |
ABN11808.1 (G1) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
|
G84G* |
Gly84 |
ABN11809.1 (G2) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
|
K84A |
Lys84Ala |
CAA19365.1 |
S. pombe |
With L85A, Y86A, N87A, P88A, E89A, recessive cold sensitive |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
L85A |
Leu85Ala |
CAA19365.1 |
S. pombe |
With K84A, Y86A, N87A, P88A, E89A, recessive cold sensitive |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
Y86A |
Tyr86Ala |
CAA19365.1 |
S. pombe |
With K84A, L85A, N87A, P88A, E89A, recessive cold sensitive |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
N87A |
Asn87Ala |
CAA19365.1 |
S. pombe |
With K84A, L85A, Y86A, P88A, E89A, recessive cold sensitive |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
N87D |
Asn87Asp |
CAA19365.1 |
S. pombe |
Suppressor of alp4-1891 mutation |
Tange et al. 2004. Genetics 167:1095-107 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
P88A |
Pro88Ala |
CAA19365.1 |
S. pombe |
With K84A, L85A, Y86A, N87A, E89A, recessive cold sensitive |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
E89A |
Glu89Ala |
CAA19365.1 |
S. pombe |
With K84A, L85A, Y86A, N87A, P88A, recessive cold sensitive |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
S7 |
F92F* |
Phe92 |
ABN11808.1 (G1) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
S7 |
F92F* |
Phe92 |
ABN11809.1 (G2) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
S7 |
Y92C |
Tyr92Cys |
ABN11808.1 (G1) |
H. sapiens |
Malformations of cortical development |
Poirier et al. 2013. Nat Genet 45:639-47 |
Homo sapiens, human |
|
|
|
S7 |
S94S* |
Ser94 |
ABN11808.1 (G1) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
S7 |
S94S* |
Ser94 |
ABN11809.1 (G2) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
|
E95X |
Glu95stop |
NP_598789.1 (Tubg2) |
M. musculus |
R1378:Tubg2, viable heterozygote, ENU mutatgenesis |
Mutagenetix |
Mus musculus, mouse |
|
|
|
|
E95X |
Glu95stop |
NP_598789.1 (Tubg2) |
M. musculus |
R1449:Tubg2, viable heterozygote, ENU mutatgenesis |
Mutagenetix |
Mus musculus, mouse |
|
|
|
|
A101G |
Ala101Gly |
AAB65830.1 |
T. thermophila |
Basal body deregulation |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H3 |
V104A |
Val104Ala |
AAB65830.1 |
T. thermophila |
Lethal |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H3 |
E111A |
Glu111Ala |
AAB65830.1 |
T. thermophila |
Wild type |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H3 |
K114A |
Lys114Ala |
AAB65830.1 |
T. thermophila |
Wild type |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
|
D116A |
Asp116Ala |
AAB65830.1 |
T. thermophila |
With D117A, cold sensitive, loss of basal bodies |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
|
E116A |
Glu116Ala |
CAA33507.1 |
A. nidulans |
With E117A and D120A, recessive lethal |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H4 |
D117A |
Asp117Ala |
AAB65830.1 |
T. thermophila |
With D116A, cold sensitive, loss of basal bodies |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H4 |
E117A |
Glu117Ala |
CAA33507.1 |
A. nidulans |
With E116A and D120A, recessive lethal |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H4 |
D120A |
Asp120Ala |
CAA33507.1 |
A. nidulans |
With E116A and E117A, recessive lethal |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H4 |
D120A |
Asp 120Ala |
CAA19365.1 |
S. pombe |
With D123A, R124A, E125A, D127A, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H4 |
D120A |
Asp120Ala |
AAB65830.1 |
T. thermophila |
Lethal |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H4 |
D123A |
Asp123Ala |
CAA33507.1 |
A. nidulans |
With R124A and E125A, weak cold sensitive |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H4 |
D123A |
Asp123Ala |
CAA19365.1 |
S. pombe |
With D120A, R124A, E125A, D127A, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H4 |
R124A |
Arg124Ala |
CAA33507.1 |
A. nidulans |
With D123A and E125A, weak cold sensitive |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H4 |
R124A |
Arg124Ala |
CAA19365.1 |
S. pombe |
With D120A, D123A, E125A, D127A, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H4 |
E125A |
Glu125Ala |
CAA33507.1 |
A. nidulans |
With D123A and R124A, weak cold sensitive |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H4 |
E125A |
Glu125Ala |
CAA19365.1 |
S. pombe |
With D120A, D123A, R124A, D127A, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H4 |
E126K |
Glu126Lys |
AAB65830.1 |
T. thermophila |
Lethal |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H4 |
D127A |
Asp127Ala |
CAA33507.1 |
A. nidulans |
With D130A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H4 |
D127A |
Asp127Ala |
CAA19365.1 |
S. pombe |
With D120A, D123A, R124A, E125A, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
S129A |
Ser129Ala |
CAA19365.1 |
S. pombe |
With D130A, S131A, E133A, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
D130A |
Asp130Ala |
CAA33507.1 |
A. nidulans |
With D127A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
D130A |
Asp130Ala |
CAA19365.1 |
S. pombe |
With S129A, S131A, E133A, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
S131A |
Ser131Ala |
CAA19365.1 |
S. pombe |
With S129A, D130A, E133A, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
S8 |
E133A |
Glu133Ala |
CAA33507.1 |
A. nidulans |
Wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
S8 |
E133A |
Glu133Ala |
CAA19365.1 |
S. pombe |
With S129A, D130A, S131A, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
S8 |
S141A |
Ser141Ala |
AAB67442.1 (Tub4p) |
S. cerevisiae |
With T146A, GTP binding |
Gombos et al. 2013. Nat Cell Biol 15:1317-27 |
Saccharomyces cerevisiae, yeast, fungus |
|
|
|
|
T146A |
Thr146Ala |
AAB67442.1 (Tub4p) |
S. cerevisiae |
With Q12G and C13G, GTP binding; with C13S, GTP binding; with S141A, GTP binding |
Gombos et al. 2013. Nat Cell Biol 15:1317-27 |
Saccharomyces cerevisiae, yeast, fungus |
|
|
|
|
T146A |
Thr146Ala |
AAB65830.1 |
T. thermophila |
Lethal |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
|
T146V |
Thr146Val |
AAB65830.1 |
T. thermophila |
Basal body deregulation |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H5 |
E155A |
Glu155Ala |
CAA33507.1 |
A. nidulans |
With R156A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H5 |
E155A |
Glu155Ala |
CAA19365.1 |
S. pombe |
With R156A, L157A, D159A, R160A, recessive cold sensitive |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H5 |
R156A |
Arg156Ala |
CAA33507.1 |
A. nidulans |
With E155A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H5 |
R156A |
Arg156Ala |
CAA19365.1 |
S. pombe |
With E155A, L157A, D159A, R160A, recessive cold sensitive |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H5 |
T156G |
Thr146Gly |
AAB65830.1 |
T. thermophila |
Lethal |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H5 |
L157A |
Leu157Ala |
CAA19365.1 |
S. pombe |
With E155A, R156A, D159A, R160A, recessive cold sensitive |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H5 |
D159A |
Asp159Ala |
CAA33507.1 |
A. nidulans |
With R160A, cold sensitive |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H5 |
D159A |
Asp159Ala |
CAA19365.1 |
S. pombe |
With E155A, R156A, L157A, R160A, recessive cold sensitive; with R160A, K163A, K164A, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H5 |
R160A |
Arg160Ala |
CAA33507.1 |
A. nidulans |
With D159A, cold sensitive |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H5 |
R160A |
Arg160Ala |
CAA19365.1 |
S. pombe |
With E155A, R156A, L157A, D159A, recessive cold sensitive; with D159A, K163A, K164A, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
K163A |
Lys163Ala |
CAA33507.1 |
A. nidulans |
With K164A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
K163A |
Lys163Ala |
CAA19365.1 |
S. pombe |
With D159A, R160A, K164A, recessive lethal; with K164A and L165V, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
S9 |
K164A |
Lys164Ala |
CAA33507.1 |
A. nidulans |
With K163A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
S9 |
K164A |
Lys164Ala |
CAA19365.1 |
S. pombe |
With D159A, R160A, K164A, recessive lethal; with K163A and L165V, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
S9 |
K164A |
Lys164Ala |
AAB65830.1 |
T. thermophila |
With K165A, weakly cold sensitive |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
S9 |
K165A |
Lys165Ala |
AAB65830.1 |
T. thermophila |
With K164A, weakly cold sensitive |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
S9 |
L165V |
Leu165Val |
CAA19365.1 |
S. pombe |
with K163A and K164A, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
D176A |
Asp176Ala |
CAA19365.1 |
S. pombe |
With E177A, S179A, D180A, cold sensitive diploid, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
D176E |
Asp176Glu |
NP_598789.1 (Tubg2) |
M. musculus |
IGL01419:Tubg2, viable heterozygote, ENU mutatgenesis |
Mutagenetix |
Mus musculus, mouse |
|
|
|
|
E177A |
Glu177Ala |
CAA19365.1 |
S. pombe |
With D176A, S179A, D180A, cold sensitive diploid, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
D179A |
Asp179Ala |
AAB65830.1 |
T. thermophila |
Lethal |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
|
S179A |
Ser179Ala |
CAA19365.1 |
S. pombe |
With D176A, E177A, D180A, cold sensitive diploid, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
D180A |
Asp180Ala |
CAA19365.1 |
S. pombe |
With D176A, E177A, S179A, cold sensitive diploid, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H6 |
K192A |
Lys192Ala |
AAB65830.1 |
T. thermophila |
With R193A, wild type |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H6 |
R192A |
Arg192Ala |
CAA33507.1 |
A. nidulans |
With R193A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H6 |
K193A |
Lys193Ala |
CAA19365.1 |
S. pombe |
With R194A and L195A, recessive cold sensitive |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H6 |
R193A |
Arg193Ala |
CAA33507.1 |
A. nidulans |
With R192A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H6 |
R193A |
Arg193Ala |
AAB65830.1 |
T. thermophila |
With K192A, wild type |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H6 |
R194A |
Arg194Ala |
CAA19365.1 |
S. pombe |
With K193A and R195A, recessive cold sensitive |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H6 |
L195A |
Leu195Ala |
CAA19365.1 |
S. pombe |
With K193A and R194A, recessive cold sensitive |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
S10 |
D200G |
Asp200Gly |
NP_598785.1 (Tubg1) |
M. musculus |
R5590:Tubg1, viable heterozygote, ENU mutatgenesis |
Mutagenetix |
Mus musculus, mouse |
|
|
|
S10 |
D205N |
Asp205Asn |
AAB65830.1 |
T. thermophila |
Lethal |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
S10 |
N206A |
Asn206Ala |
AAB67442.1 (Tub4p) |
S. cerevisiae |
GTP binding |
Gombos et al. 2013. Nat Cell Biol 15:1317-27 |
Saccharomyces cerevisiae, yeast, fungus |
|
|
|
H7 |
K211A |
Lys211Ala |
AAB65830.1 |
T. thermophila |
Weak cold sensitive |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H7 |
R211A |
Arg211Ala |
CAA33507.1 |
A. nidulans |
Wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H7 |
R215A |
Arg215Ala |
CAA33507.1 |
A. nidulans |
With R216A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
R216A |
Arg216Ala |
CAA33507.1 |
A. nidulans |
With R215A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
I224A |
Ile224Ala |
AAB65830.1 |
T. thermophila |
Lethal |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
|
L224A |
Leu224Ala |
AAB67442.1 (Tub4p) |
S. cerevisiae |
GTP binding; with N206A, GTP binding |
Gombos et al. 2013. Nat Cell Biol 15:1317-27 |
Saccharomyces cerevisiae, yeast, fungus |
|
|
|
|
N228A |
Asn228Ala |
AAB67442.1 (Tub4p) |
S. cerevisiae |
GTP binding |
Gombos et al. 2013. Nat Cell Biol 15:1317-27 |
Saccharomyces cerevisiae, yeast, fungus |
|
|
|
H8 |
L230T |
Leu230Thr |
AAB65830.1 |
T. thermophila |
Lethal |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H8 |
T233A |
Thr233Ala |
AAB65830.1 |
T. thermophila |
Wild type |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
|
R243A |
Arg243Ala |
CAA33507.1 |
A. nidulans |
Weak heat sensitive |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
R243A |
Arg243Ala |
AAB65830.1 |
T. thermophila |
Cold sensitive, loss of basal bodies |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
|
L250L* |
Leu250 |
ABN11808.1 (G1) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
|
L250L* |
Leu250 |
ABN11809.1 (G2) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
|
D251A |
Asp251Ala |
AAB65830.1 |
T. thermophila |
Wild type |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
|
R264A |
Arg264Ala |
CAA33507.1 |
A. nidulans |
With H266A, recessive lethal |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
H266A |
His266Ala |
CAA33507.1 |
A. nidulans |
With R264A, recessive lethal |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
S11 |
M270K |
Met270Lys |
NP_598785.1 (Tubg1) |
M. musculus |
R4090:Tubg1, viable heterozygote, ENU mutatgenesis |
Mutagenetix |
Mus musculus, mouse |
|
|
|
S11 |
I274A |
Ile274Ala |
AAB65830.1 |
T. thermophila |
Lethal |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
|
D278A |
Asp278Ala |
CAA33507.1 |
A. nidulans |
With D281A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
D278A |
Asp278Ala |
AAB65830.1 |
T. thermophila |
Wild type |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
|
A280A* |
Ala280 |
ABN11808.1 (G1) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
|
D281A |
Asp281Ala |
CAA33507.1 |
A. nidulans |
With D278A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
I282I* |
Ile282 |
ABN11808.1 (G1) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
|
I282I* |
Ile282 |
ABN11809.1 (G2) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
|
K284A |
Lys284Ala |
CAA33507.1 |
A. nidulans |
With R287A and K288A, cold sensitive |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
R285A |
Arg285Ala |
AAB65830.1 |
T. thermophila |
With D291A, cold sensitive |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
|
R285D |
Arg285Asp |
AAB65830.1 |
T. thermophila |
With K286D, cold sensitive, loss of basal bodies |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
|
R285E |
Arg285Glu |
AAB65830.1 |
T. thermophila |
Wild type |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
|
R285Q |
Arg285Gln |
AAB65830.1 |
T. thermophila |
Wild type |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
|
K286D |
Lys286Asp |
AAB65830.1 |
T. thermophila |
With R285D, cold sensitive, loss of basal bodies |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
|
K286E |
Lys286Glu |
AAB65830.1 |
T. thermophila |
Cold sensitive, loss of basal bodies |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
|
R286A |
Arg286Ala |
CAA19365.1 |
S. pombe |
With K287A and T288A, recessive cold sensitive |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
K287A |
Lys287Ala |
CAA19365.1 |
S. pombe |
With R286A and T288A, recessive cold sensitive |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
K287E |
Lys287Glu |
NP_598789.1 (Tubg2) |
M. musculus |
R6156:Tubg2, viable heterozygote, ENU mutatgenesis |
Mutagenetix |
Mus musculus, mouse |
|
|
|
|
R287A |
Arg287Ala |
CAA33507.1 |
A. nidulans |
With K284A and K288A, cold sensitive |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
K288A |
Lys288Ala |
CAA33507.1 |
A. nidulans |
With K284A and R287A, cold sensitive |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
T288A |
Arg286Ala |
CAA19365.1 |
S. pombe |
With R286A and K287A, recessive cold sensitive |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H10 |
D291A |
Asp291Ala |
AAB65830.1 |
T. thermophila |
With R285A, cold sensitive |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H10 |
D292A |
Asp292Ala |
CAA19365.1 |
S. pombe |
With R295A, R296A, R297A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H10 |
D293A |
Asp293Ala |
CAA33507.1 |
A. nidulans |
With D296A and R297A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H10 |
R294A |
Arg294Ala |
AAB65830.1 |
T. thermophila |
With R295A, lethal |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H10 |
R295A |
Arg295Ala |
CAA19365.1 |
S. pombe |
With D292A, R296A, R297A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H10 |
R295A |
Arg295Ala |
AAB65830.1 |
T. thermophila |
With R294A, lethal |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H10 |
R296A |
Arg296Ala |
CAA33507.1 |
A. nidulans |
With D293A and R297A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H10 |
R296A |
Arg296Ala |
CAA19365.1 |
S. pombe |
With D292A, R295A, R297A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H10 |
P297P* |
Pro297 |
ABN11809.1 (G2) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
H10 |
R297A |
Arg297Ala |
CAA33507.1 |
A. nidulans |
With D293A and R296A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H10 |
R297A |
Arg297Ala |
CAA19365.1 |
S. pombe |
With D292A, R295A, R296A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
L301S |
Leu301Ser |
CAA19365.1 |
S. pombe |
Suppressor of alp4-1891 mutation |
Tange et al. 2004. Genetics 167:1095-107 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
K302A |
Lys302Ala |
CAA33507.1 |
A. nidulans |
With R304A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
P302L |
Pro302Leu |
CAA19365.1 |
S. pombe |
Suppressor of alp4-1891 mutation, synthetic lethal with Pkl1 |
Paluh et al. 2000. Mol Biol Cell 11:1225-39, Tange et al. 2004. Genetics 167:1095-107 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
P302S |
Pro302Ser |
CAA19365.1 |
S. pombe |
With V307I, suppressor of alp4-1891 mutation |
Tange et al. 2004. Genetics 167:1095-107 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
P303P* |
Pro303 |
ABN11808.1 (G1) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
|
R304A |
Arg304Ala |
CAA33507.1 |
A. nidulans |
With K302A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
V304A |
Val304Ala |
AAB65830.1 |
T. thermophila |
Slow growth at 30 C |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
|
V307I |
Val307Ile |
CAA19365.1 |
S. pombe |
With P302S, suppressor of alp4-1891 mutation |
Tange et al. 2004. Genetics 167:1095-107 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
R309A |
Arg309Ala |
CAA19365.1 |
S. pombe |
With D310A and R311A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
D310A |
Asp310Ala |
CAA19365.1 |
S. pombe |
With D309A and R311A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
R311A |
Arg311Ala |
CAA19365.1 |
S. pombe |
With R309A and D310A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
S12 |
Y317H |
Tyr317His |
NP_598789.1 (Tubg2) |
M. musculus |
IGL02693:Tubg2, viable heterozygote, ENU mutatgenesis |
Mutagenetix |
Mus musculus, mouse |
|
|
|
S13 |
E326A |
Glu326Ala |
CAA33507.1 |
A. nidulans |
With D328A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
D328A |
Asp328Ala |
CAA33507.1 |
A. nidulans |
With E326A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H11 |
D331A |
Asp331Ala |
CAA33507.1 |
A. nidulans |
With K334A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H11 |
T331P |
Tyr331Pro |
ABN11808.1 (G1) |
H. sapiens |
Malformations of cortical development |
Poirier et al. 2013. Nat Genet 45:639-47 |
Homo sapiens, human |
|
|
|
H11 |
K334A |
Lys334Ala |
CAA33507.1 |
A. nidulans |
With D331A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H11 |
R335A |
Arg335Ala |
AAB65830.1 |
T. thermophila |
With R337A, wild type |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H11 |
R337A |
Arg337Ala |
AAB65830.1 |
T. thermophila |
With R335A, wild type |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H11 |
E338K |
Glu338Lys |
AAB65830.1 |
T. thermophila |
Lethal |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H11 |
R338A |
Arg338Ala |
CAA33507.1 |
A. nidulans |
With R340A, cold sensitive |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H11 |
R339A |
Arg339Ala |
CAA19365.1 |
S. pombe |
With R341A, E342A, R343A, K344A, cold sensitive diploid, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H11 |
R340A |
Arg340Ala |
CAA33507.1 |
A. nidulans |
With R338A, cold sensitive |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H11 |
R341A |
Arg341Ala |
CAA33507.1 |
A. nidulans |
With R342A and R343A, recessive lethal |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H11 |
R341A |
Arg341Ala |
CAA19365.1 |
S. pombe |
With R339A, E342A, R343A, K344A, cold sensitive diploid, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H11 |
E342A |
Glu342Ala |
CAA19365.1 |
S. pombe |
With R339A, R341A, R343A, K344A, cold sensitive diploid, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H11 |
R342A |
Arg342Ala |
CAA33507.1 |
A. nidulans |
With R341A and R343A, recessive lethal |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H11 |
R343A |
Arg343Ala |
CAA33507.1 |
A. nidulans |
With R341A and R342A, recessive lethal |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H11 |
R343A |
Arg343Ala |
CAA19365.1 |
S. pombe |
With R339A, R341A, E342A, K344A, cold sensitive diploid, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
K344A |
Lys344Ala |
CAA19365.1 |
S. pombe |
With R339A, R341A, E342A, R343A, cold sensitive diploid, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
S14 |
K358A |
Lys358Ala |
AAB65830.1 |
T. thermophila |
With K359A, cold sensitive, loss of basal bodies |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
S14 |
K359A |
Lys359Ala |
AAB65830.1 |
T. thermophila |
With K358A, cold sensitive, loss of basal bodies |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
S14 |
R361A |
Arg361Ala |
CAA33507.1 |
A. nidulans |
With K362A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
S14 |
K362A |
Lys362Ala |
CAA33507.1 |
A. nidulans |
With R361A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
S14 |
R362A |
Arg362Ala |
CAA19365.1 |
S. pombe |
With K363A and S364A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
K363A |
Lys363Ala |
CAA19365.1 |
S. pombe |
With R362A and S364A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
S364A |
Ser364Ala |
CAA19365.1 |
S. pombe |
With R362 and K363A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
H367A |
His367Ala |
AAB65830.1 |
T. thermophila |
With K368A, wild type |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
|
K368A |
Lys368Ala |
AAB65830.1 |
T. thermophila |
With H367A, wild type |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
|
H370A |
His370Ala |
CAA33507.1 |
A. nidulans |
With R371A, weak cold sensitive |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
R371A |
Arg371Ala |
CAA33507.1 |
A. nidulans |
With H370A, weak cold sensitive |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
S15 |
M377T |
Met377Thr |
NP_598785.1 (Tubg1) |
M. musculus |
R0599:Tubg1, viable heterozygote, ENU mutatgenesis |
Mutagenetix |
Mus musculus, mouse |
|
|
|
H12 |
L387P |
Leu387Pro |
ABN11808.1 (G1) |
H. sapiens |
Malformations of cortical development |
Poirier et al. 2013. Nat Genet 45:639-47 |
Homo sapiens, human |
|
|
|
H12 |
K388A |
Lys388Ala |
CAA33507.1 |
A. nidulans |
With R389A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H12 |
E389A |
Glu389Ala |
CAA19365.1 |
S. pombe |
With R390A, T391A, R393A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H12 |
R389A |
Arg389Ala |
CAA33507.1 |
A. nidulans |
With K388A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H12 |
R390A |
Glu389Ala |
CAA19365.1 |
S. pombe |
With E389A, T391A, R393A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H12 |
I391I* |
Ile391 |
ABN11808.1 (G1) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
H12 |
T391A |
Thr391Ala |
CAA19365.1 |
S. pombe |
With E389A, R390A, R393A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
R393A |
Arg393Ala |
CAA19365.1 |
S. pombe |
With E389A, R390A, T391A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H12 |
R394R* |
Arg394 |
ABN11808.1 (G1) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
H12 |
S394S* |
Ser394 |
ABN11809.1 (G2) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
H12 |
D395A |
Asp395Ala |
CAA33507.1 |
A. nidulans |
With R396A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H12 |
N395N* |
Asn395 |
ABN11809.1 (G2) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
H12 |
D396A |
Asp396Ala |
CAA19365.1 |
S. pombe |
With K397A, R399A, K400A, R401A, E402A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H12 |
N396N* |
Asn396 |
ABN11808.1 (G1) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
H12 |
N396N* |
Asn396 |
ABN11809.1 (G2) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
H12 |
K396A |
Lys396Ala |
AAB65830.1 |
T. thermophila |
With K397A, wild type |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H12 |
R396A |
Arg396Ala |
CAA33507.1 |
A. nidulans |
With D395A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H12 |
K397A |
Lys397Ala |
CAA19365.1 |
S. pombe |
With D396A, R399A, K400A, R401A, E402A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H12 |
K397A |
Lys397Ala |
AAB65830.1 |
T. thermophila |
With K396A, wild type |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H12 |
R398A |
Arg398Ala |
CAA33507.1 |
A. nidulans |
With K399A and R400A, recessive lethal |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H12 |
K399A |
Lys399Ala |
CAA33507.1 |
A. nidulans |
With R398A and R400A, recessive lethal |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H12 |
R399A |
Arg399Ala |
CAA19365.1 |
S. pombe |
With D396A, K397A, K400A, R401A, E402A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H12 |
D400D* |
Asp400 |
ABN11808.1 (G1) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
H12 |
K400A |
Lys400Ala |
CAA19365.1 |
S. pombe |
With D396A, K397A, R399A, R401A, E402A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H12 |
R400A |
Arg400Ala |
CAA33507.1 |
A. nidulans |
With R398A and K399A, recessive lethal |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H12 |
N401N* |
Asn401 |
ABN11808.1 (G1) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
H12 |
R401A |
Arg401Ala |
CAA19365.1 |
S. pombe |
With D396A, K397A, R399A, K400A, E402A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H12 |
T401T* |
Thr401 |
ABN11809.1 (G2) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
|
E402A |
Glu402Ala |
CAA19365.1 |
S. pombe |
With D396A, K397A, R399A, K400A, R401A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
Q403Q* |
Gln403 |
ABN11809.1 (G2) |
E. focardii |
Cold stable microtubules |
Marziale et al. 2008. FEBS J 275:5367-82, Pucciarelli et al. 2009. Mar Genomics 2:57-66 |
Euplotes focardii, extremophile, Antarctic ciliate |
|
|
|
|
K405A |
Lys405Ala |
AAB65830.1 |
T. thermophila |
With K406A, lethal |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
|
E406A |
Glu406Ala |
CAA19365.1 |
S. pombe |
With R409A, K410A, E411A, D412A, cold sensitive diploid |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
K406A |
Lys406Ala |
AAB65830.1 |
T. thermophila |
With K405A, lethal |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
|
K408A |
Lys408Ala |
CAA33507.1 |
A. nidulans |
With K409A and E410A, benomyl dependent |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
K409A |
Lys409Ala |
CAA33507.1 |
A. nidulans |
With K408A and E410A, benomyl dependent |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
R409A |
Arg409Ala |
CAA19365.1 |
S. pombe |
With E406A, K410A, E411A, D412A, cold sensitive diploid |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
E410A |
Glu410Ala |
CAA33507.1 |
A. nidulans |
With K408A and K409A, benomyl dependent |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
K410A |
Lys410Ala |
CAA19365.1 |
S. pombe |
With E406A, R409A, E411A, D412A, cold sensitive diploid |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
E411A |
Glu411Ala |
CAA19365.1 |
S. pombe |
With E406A, R409A, K410A, D412A, cold sensitive diploid |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
D412A |
Asp412Ala |
CAA19365.1 |
S. pombe |
With E406A, R409A, K410A, E411A, cold sensitive diploid |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
D415A |
Asp415Ala |
CAA33507.1 |
A. nidulans |
With D418A and E419A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
K415A |
Lys415Ala |
CAA19365.1 |
S. pombe |
With D416A and N417A, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
D416A |
Asp416Ala |
CAA19365.1 |
S. pombe |
With K415A and N417A, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
N417A |
Asn417Ala |
CAA19365.1 |
S. pombe |
With K415A and D416A, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H13 |
D418A |
Asp418Ala |
CAA33507.1 |
A. nidulans |
With D415A and E419A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H13 |
D419A |
Asp419Ala |
CAA19365.1 |
S. pombe |
With E420A and D422A, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H13 |
E419A |
Glu419Ala |
CAA33507.1 |
A. nidulans |
With D415A and F418A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H13 |
E420A |
Glu420Ala |
CAA19365.1 |
S. pombe |
With D419A and D422A, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H13 |
D421A |
Asp421Ala |
CAA33507.1 |
A. nidulans |
With E422A and R424A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H13 |
D422A |
Asp422Ala |
CAA19365.1 |
S. pombe |
With D419A and E420A, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H13 |
E422A |
Glu422Ala |
CAA33507.1 |
A. nidulans |
With D421A and R424A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H13 |
R424A |
Arg424Ala |
CAA33507.1 |
A. nidulans |
With D421A and E422A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H13 |
R425A |
Arg425Ala |
CAA19365.1 |
S. pombe |
With E426A and I427A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H13 |
E426A |
Glu426Ala |
CAA19365.1 |
S. pombe |
With R425A and I427A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H13 |
I427A |
Ile427Ala |
CAA19365.1 |
S. pombe |
With R425A and E426A, wild type |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H13 |
D429A |
Asp429Ala |
CAA33507.1 |
A. nidulans |
Wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H13 |
Y429A |
Tyr429Ala |
AAB65830.1 |
T. thermophila |
Lethal |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H13 |
Y429E |
Tyr429Glu |
AAB65830.1 |
T. thermophila |
Lethal |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H13 |
Y429F |
Tyr429Phe |
AAB65830.1 |
T. thermophila |
Cold sensitive, loss of basal bodies |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H13 |
Δ429-449 |
Δ429-449 |
AAB65830.1 |
T. thermophila |
Lethal |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H13 |
Δ430-449 |
Δ430-449 |
AAB65830.1 |
T. thermophila |
Wild type |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
H13 |
D433A |
Asp433Ala |
CAA19365.1 |
S. pombe |
With E434A and Y435A, cold sensitive diploid, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H13 |
D433X |
Asp433stop |
AAF34188.1 |
H. sapiens |
No localization to centrosomes |
Leask and Stearns. 1998. J Biol Chem 273:2661-8 |
Homo sapiens, human |
|
|
|
H13 |
E433A |
Glu433Ala |
CAA33507.1 |
A. nidulans |
With E435A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H13 |
E434A |
Glu434Ala |
CAA19365.1 |
S. pombe |
With D433A and Y435A, cold sensitive diploid, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
H13 |
E435A |
Glu433Ala |
CAA33507.1 |
A. nidulans |
With E433A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
H13 |
Y435A |
Tyr435Ala |
CAA19365.1 |
S. pombe |
With D433A and E434A, cold sensitive diploid, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
Y437D |
Tyr437Asp |
AAB65830.1 |
T. thermophila |
Wild type |
Shang et al. 2005. J Cell Biol 171:1035-44 |
Tetrahymena thermophila |
|
|
|
|
E438A |
Glu438Ala |
CAA33507.1 |
A. nidulans |
With R439A and E440A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
R439A |
Arg439Ala |
CAA33507.1 |
A. nidulans |
With E438A and E440A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
E440A |
Glu440Ala |
CAA33507.1 |
A. nidulans |
With E438A and R439A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
R440A |
Arg440Ala |
CAA19365.1 |
S. pombe |
With P441A and D442A, cold sensitive diploid, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
P441A |
Pro441Ala |
CAA19365.1 |
S. pombe |
With R440A and D442A, cold sensitive diploid, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
D442A |
Asp442Ala |
CAA19365.1 |
S. pombe |
With R440A and P441A, cold sensitive diploid, recessive lethal |
Hendrickson et al. 2001. Mol Biol Cell 12:2469-81 |
Schizosaccharomyces pombe, fission yeast, fungus |
|
|
|
|
D442X |
Asp442stop |
AAF34188.1 |
H. sapiens |
No localization to centrosomes |
Leask and Stearns. 1998. J Biol Chem 273:2661-8 |
Homo sapiens, human |
|
|
|
|
D443-D447 |
DAsp443-Asp447 |
AAB67442.1 (Tub4p) |
S. cerevisiae |
Temperature-sensitive growth |
Vogel and Snyder. 2000. J Cell Sci 113:3871-82 |
Saccharomyces cerevisiae, yeast, fungus |
|
|
|
|
D444A |
Asp444Ala |
CAA33507.1 |
A. nidulans |
With D446A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
Y445D |
Tyr445Asp |
AAB67442.1 (Tub4p) |
S. cerevisiae |
Anaphase arrest, benomyl resistant |
Vogel et al. 2001. Dev Cell 1:621-31 |
Saccharomyces cerevisiae, yeast, fungus |
|
|
|
|
Y445X |
Tyr445Stop |
AAB67442.1 (Tub4p) |
S. cerevisiae |
Temperature-sensitive growth |
Vogel and Snyder. 2000. J Cell Sci 113:3871-82 |
Saccharomyces cerevisiae, yeast, fungus |
|
|
|
|
D446A |
Asp446Ala |
CAA33507.1 |
A. nidulans |
With D444A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
K449A |
Lys449Ala |
CAA33507.1 |
A. nidulans |
With D450A and E451A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
V449X |
Val449Stop |
AAB67442.1 (Tub4p) |
S. cerevisiae |
Temperature-sensitive growth |
Vogel and Snyder. 2000. J Cell Sci 113:3871-82 |
Saccharomyces cerevisiae, yeast, fungus |
|
|
|
|
D450A |
Asp450Ala |
CAA33507.1 |
A. nidulans |
With K449A and E451A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|
|
|
|
E451A |
Glu451Ala |
CAA33507.1 |
A. nidulans |
With K449A and D450A, wild type |
Jung et al. 2001. Mol Biol Cell 12:2119-36 |
Aspergillus nidulans, fungus |
|